Therapeutics are always going to be necessary...Now with this new SCIEX 7500 System, we have another level of sensitivity. SCIEX has again set the bar.
SHANE NEEDHAM Chief Founding Scientist Alturas Analytics, Moscow, ID
You have to look for different substances in water and some substances are very difficult to measure because of the sensitivity of current instruments. Before now we didn’t know they were in the water because the methods weren’t sensitive enough.
BERNARD BAJEMA Project Leader Vitens, Netherlands
The drive to improve pesticide detection limits is not just from legislation, but also from the demands of consumers. Faster and more sensitive technology prepares us for those situations to allow us to get lower and we will if required.
WIM BROER Manager, Science and Development Nofalab, Netherlands
When an instrument is sensitive, we can do direct water injection. We don’t need sample prep to concentrate the samples, that is the big advantage of sensitive machines.
RONNY BOSCH Senior Analyst Vitens, Netherlands
SENSITIVITY GAINS FOR THE EVOLUTION OF ROUTINE BIOANALYSIS
The rapid advancement of the drug pipeline demands sensitivity to allow a more complete pharmacokinetic characterization of low-dose drug candidates, below detection limits. The SCIEX 7500 System will enable pharmaceutical researchers to continue to explore lower dosage, higher efficacy compounds, and improve the efficiency of routine bioanalysis.
Quantification of peptide/protein therapeutics in biological matrices is crucial for therapeutic development. Download the technical note that demonstrates a robust method using the SCIEX 7500 System to quantify a series of surrogate peptides in rat plasma at ultra-low LLOQs —5 to 39 fmol/mL.
ULTRA-SENSITIVE QUANTIFICATION OF INTACT PEPTIDE HORMONE IN RAT PLASMA
Quantifying intact peptide hormone analogs is challenging for because of low ionization and CID fragmentation efficiency related to the high molecular weights, low concentrations in matrices that require ultra-high assay sensitivity, and endogenous inferences from natural intact peptide hormones. Enter the SCIEX 7500 System. Read more about the sensitive LC-MRM method to quantify intact peptide hormones in rat plasma.
IMPROVED LC-MRM WORKFLOW FOR CYCLIC PEPTIDE QUANTIFICATION ON NATRIURETIC PEPTIDE FAMILY
Quantifying trace level cyclic peptides in biological matrices is extremely challenging. The SCIEX 7500 System can offer outstanding reproducibility, precision, accuracy, and linearity to ease these challenges. Download this ultra-sensitive MRM based cyclic peptide quantification workflow.
ENHANCING THE SENSITIVITY OF PEPTIDE QUANTIFICATION FOR THE TARGETED HOST CELL PROTEINS ANALYSIS
There are important requirements for the quantitative measurement of host cell proteins (HCP) across the entire development paradigm. Learn about the targeted high sensitivity, analysis throughput, robustness and multiplexing capability approach using the SCIEX 7500 System.
BROAD LIPID QUANTIFICATION USING A HIGH- THROUGHPUT TARGETED LIPIDOMICS METHOD
The complexity of the lipidome is very high with a huge diversity in lipid molecular species making comprehensive quantitative profiling challenging. Download this technical note to find out about a targeted MRM assay approach which enables quantification of a broad array of different lipids at the molecular species level using the SCIEX 7500 System.
Detecting and quantifying pesticide residues in food remains a moving target as food regulations drive the pursuit of lower limits of quantification. This work demonstrates the high sensitivity of the SCIEX 7500 System in quantifying 209 pesticides, easily achieving sub-ppb detection limits with a very small injection volume.
PRECISE TESTING OF PESTICIDES IN FOOD USING THE SCIEX 7500 SYSTEM
The global scale of pesticide use, its impact on food safety and authenticity regulations have led to the need for sensitivity analysis that can achieve trace levels. Download the technical note to learn more about how the SCIEX 7500 System offers sensitivity, robustness and accuracy with 700 compounds achieving limits low as 0.2 ng/mL.
THE DIRECT AQUEOUS ANALYSIS OF PESTICIDES AND PPCP's, IN DRINKING AND BOTTLED WATER USING THE SCIEX 7500 SYSTEM
Drinking water analysis is subjected to extremely low and rigid prescribed consent values (PCV) for determinands, including pesticides, pharmaceuticals and personal care products. In collaboration with Vitens Water Company, we demonstrated the sensitivity levels of the SCIEX 7500 System for low-level quantification across a relatively large suite of 431 determinands.
FUTURE-PROOFING CANNABIS ANALYSIS WITH THE SCIEX 7500 SYSTEM
As the cannabis market emerges globally, more stringent and lower level pesticide regulations may come into force. The SCIEX 7500 System shows its levels of sensitivity across a broad suite of regulated pesticides coupled with ruggedness and robustness for continued analysis of cannabis extracts.
HIGH-SENSITIVITY DETECTION OF FORENSIC DRUG PANEL IN HUMAN WHOLE BLOOD
In a forensic laboratory, the ability to accurately quantify large panels of analytes in complex biological matrices over a wide range of concentration is challenging and often requires dilution of the samples to bring them within the calibration range of the instrument. In this technical note, the SCIEX 7500 System demonstrates exceptional performance in speed, linear dynamic range and sensitivity to overcome this challenge, quantifying a panel of 49 drugs in human whole blood.
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