ZenoTOF 7600システムを使用した文献

ZenoTOF 7600システムは、ASMS 2021で発売された新しいQTOFシステムです。ZenoTOF 7600システムの主な技術的進歩は、大幅に向上したMS/MS感度と新しい直交フラグメントモードであるEAD(Electron Activated Dissociation:電子励起解離)の両方を提供します。 このハイブリッドコリジョンセルは、ZenoTOF 7600 システムの技術的進歩の中核をなすものです。

これらの文献から、このテクノロジーと実現したアプリケーションの詳細をご覧ください。

 

Zeno trapテクノロジー

 

EAD(Electron Activated Dissociation:電子励起解離)テクノロジー

 

プロテオーム解析

 

タンパク質/ペプチド特性解析

 

糖鎖と糖ペプチドの特性解析

  • Baba T, Zhang Z, Liu S, Burton L, Ryumin P, Le Blanc JCY. (2022) Localization of Multiple O-Linked Glycans Exhibited in Isomeric Glycopeptides by Hot Electron Capture Dissociation. J. Proteome Res.

 

代謝物・低分子化合物解析

  • Kanako Tokiyoshi, Yuki Matsuzawa, Mikiko Takahashi, Hiroaki Takeda, Mayu Hasegawa, Junki Miyamoto, Hiroshi Tsugawa. Using Data-Dependent and -Independent Hybrid Acquisitions for Fast Liquid Chromatography-Based Untargeted Lipidomics. Anal Chem. 2024 Jan 11. doi: 10.1021/acs.analchem.3c04400. Online ahead of print.
  • Ducati AO, Ruskic D, Sosnowski P, Baba T, Bonner R, Hopfgartner, G. (2021) Improved metabolite characterization by liquid chromatography – Tandem mass spectrometry through electron impact type fragments from adduct ions. Analytica chimica acta, 1150, 338207.
  • Huang L, Drouin N, Causon J, Wegrzyn A, Castro-Perez J, Fleming R, Harms A, Hankemeier T. (2023) Reconstruction of Glutathione Metabolism in the Neuronal Model of Rotenone-Induced Neurodegeneration Using Mass Isotopologue Analysis with Hydrophilic Interaction Liquid Chromatography-Zeno High-Resolution Multiple Reaction Monitoring. Anal. Chem. 95, 6, 3255–3266.

 

脂質解析

  • Baba T, Campbell JL, Le Blanc JCY, Baker PRS. (2018) Quantitative structural multi-class lipidomics using differential mobility- Electron Impact Excitation of Ions from Organics (EIEIO) mass spectrometry. Journal of lipid research, 59(5), 910-919.
  • Baba T, Campbell JL, Le Blanc J, Baker P. (2017) Distinguishing Cis and Trans Isomers in Intact Complex Lipids Using Electron Impact Excitation of Ions from Organics Mass Spectrometry. Analytical chemistry, 89(14), 7307–7315.
  • Baba T, Campbell JL, Le Blanc JC, Baker PR. (2016) Structural identification of triacylglycerol isomers using electron impact excitation of ions from organics (EIEIO). Journal of lipid research, 57(11), 2015–2027.
  • Baba T, Campbell JL, Le Blanc, JC, Baker PR. (2016) In-depth sphingomyelin characterization using electron impact excitation of ions from organics and mass spectrometry. Journal of lipid research, 57(5), 858–867.
  • Campbell JL, Baba T. (2015) Near-complete structural characterization of phosphatidylcholines using electron impact excitation of ions from organics. Analytical Chemistry, 2;87(11), 5837-45.

 

オリゴヌクレオチド/核酸

  • Yixuan Xie, Francisca N. De Luna Vitorino, Ye Chen, Joanna K. Lempiäinen, Chenfeng Zhao, Robert T. Steinbock, Xingyu Liu, Zongtao Lin, Emily Zahn, Arabella L. Garcia, Matthew D. Weitzman, Benjamin A. Garcia. SWAMNA: a comprehensive platform for analysis of nucleic acid modifications (2023)
  • Anand P, Koleto M, Kandula DR, Xiong L, MacNeill R. (2021) Novel hydrophilic-phase extraction, HILIC and high-resolution MS quantification of an RNA oligonucleotide in plasma. Bioanalysis, 14(1), epub.
  • Karasawa K, Duchoslav E, Takashi Baba T. (2022) Fast Electron Detachment Dissociation of Oligonucleotides in Electron-Nitrogen Plasma Stored in Magneto Radio-Frequency Ion Traps. Anal. Chem. 94, 44, 15510–15517.