2018年7月3日~7日にサンディエゴで開催されましたASMS 2018において、SCIEXが発表しましたポスター等をアプリケーションごとに紹介しております。

皆様おなじみの低分子化合物の高感度定量例から、ペプチド・抗体の定量・近年注目を集めておりますバイオ医薬品の特性解析例までLC-MS/MSを用いた事例を幅広くご紹介いたします。食品・農薬・環境分野での新しい評価法についても、ご紹介しております。
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・低分子化合物

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低分子化合物

Acoustic-Open Port-Mass Spectrometry (AOMS): A New Platform for Ultrafast, Direct Human Plasma Quantitative Sample Analysis

Acoustic-Open Port-Mass Spectrometry (AOMS): A New Platform for Ultrafast, Direct Human Plasma Quantitative Sample Analysis

 


Highly Selective Bioanalytical Quantitation Method for Analysis of R and S Amlodipine Enantiomers in Human Plasma Using LC-MS/MS

Highly Selective Bioanalytical Quantitation Method for Analysis of R and S Amlodipine Enantiomers in Human Plasma Using LC-MS/MS


Improved Sensitivity for LC-MS Quantitation of Pharmaceutical Compounds in Human Plasma with MicroLC Using a New Microflow Source Design

Improved Sensitivity for LC-MS Quantitation of Pharmaceutical Compounds in Human Plasma with MicroLC Using a New Microflow Source Design


Impurity Profiling of Amiodarone Stability Study Samples Using PDA and Accurate Mass Analysis with Automated Software Processing

Impurity Profiling of Amiodarone Stability Study Samples Using PDA and Accurate Mass Analysis with Automated Software Processing


Scanning SWATH® Acquisition Method for Improved Compound Screening

Scanning SWATH® Acquisition Method for Improved Compound Screening


SCIEX Solution for Highly Sensitive LC-MS/MS Method for the Quantification of Mometasone Furoate in Human Plasma Using SCIEX QTRAP® 6500 System

SCIEX Solution for Highly Sensitive LC-MS/MS Method for the Quantification of Mometasone Furoate in Human Plasma Using SCIEX QTRAP® 6500 System

ペプチド・タンパク質定量

Improved Sensitivity for LC-MS Quantitation of Trastuzumab Emtansine in Rat Plasma with Trap-and-Elute MicroLC Using a New Microflow Source

Improved Sensitivity for LC-MS Quantitation of Trastuzumab Emtansine in Rat Plasma with Trap-and-Elute MicroLC Using a New Microflow Source


Metabolite Profiling and ID of Cyclic Peptides Using Automated Software Processing and High Resolution Mass Spectrometry

Metabolite Profiling and ID of Cyclic Peptides Using Automated Software Processing and High Resolution Mass Spectrometry


Quantitation of Intact Therapeutic Protein in Plasma Matrix by LC/MS

Quantitation of Intact Therapeutic Protein in Plasma Matrix by LC/MS


Sensitive Quantitation of the ADC Ado-trastuzumab Emtansine Free Cytotoxic Drug DM1 in Serum Using MicroLC-MS

Sensitive Quantitation of the ADC Ado-trastuzumab Emtansine Free Cytotoxic Drug DM1 in Serum Using MicroLC-MS


Using Electrokinetic Injection to Increase Throughput and Improve Sensitivity in the Detection of Proteins by CE-MS

Using Electrokinetic Injection to Increase Throughput and Improve Sensitivity in the Detection of Proteins by CE-MS

バイオ医薬品の特性解析

BiopharmaView™ Software for Fast and Efficient Monitoring of pH Induced Deamidation

BiopharmaView™ Software for Fast and Efficient Monitoring of pH Induced Deamidation


Capillary Electrophoresis Analysis of Anionically Tagged N-linked Carbohydrates by Simultaneous LIF and MS Detection

Capillary Electrophoresis Analysis of Anionically Tagged N-linked Carbohydrates by Simultaneous LIF and MS Detection


Characterization of Biologic Compounds with Differential Mobility and SWATH® Acquisition

Characterization of Biologic Compounds with Differential Mobility and SWATH® Acquisition


Characterization of Intact Monoclonal Antibodies Under Native and Reverse Phase Conditions Using High Resolution Mass Spectrometry

Characterization of Intact Monoclonal Antibodies Under Native and Reverse Phase Conditions Using High Resolution Mass Spectrometry


Characterization of NIST Monoclonal Antibody on Intact, Subunit, and Peptide Level with Monitoring of CQA’s on the X500B

Characterization of NIST Monoclonal Antibody on Intact, Subunit, and Peptide Level with Monitoring of CQA’s on the X500B


Effect of Supercharging Reagents in Protein Identification

Effect of Supercharging Reagents in Protein Identification


Monitoring of Sequence Variants by MAM Using High Resolution Mass Spectrometry

Monitoring of Sequence Variants by MAM Using High Resolution Mass Spectrometry


Multi-Attribute Monitoring (MAM) of Oxidized NIST mAb Using BioPharmaView™ Workflow

Multi-Attribute Monitoring (MAM) of Oxidized NIST mAb Using BioPharmaView™ Workflow


Separation of Intact Protein Isoforms with Differential Mobility

Separation of Intact Protein Isoforms with Differential Mobility


Top-Down & Middle-Down Sequencing of Immunoglobulin Using Electron Capture Dissociation – Time of Flight Mass Spectrometer Combined with Online Disulfide Bond Reduction

Top-Down & Middle-Down Sequencing of Immunoglobulin Using Electron Capture Dissociation – Time of Flight Mass Spectrometer Combined with Online Disulfide Bond Reduction


Towards a Complete Non-Linear Peptide MS/MS Characterization

Towards a Complete Non-Linear Peptide MS/MS Characterization

バイオマーカー

Identification of Lipid Biomarkers in CAD Using a Targeted Liquid Chromatography Mass Spectrometry Approach

Identification of Lipid Biomarkers in CAD Using a Targeted Liquid Chromatography Mass Spectrometry Approach


Separation of Bile Acid Isomers Based on Differential Mobility Spectrometry

Separation of Bile Acid Isomers Based on Differential Mobility Spectrometry


Strategies for Detection and Quantification of Metabolites in SWATH® Acquisition Analysis

Strategies for Detection and Quantification of Metabolites in SWATH® Acquisition Analysis

メタボロミクス/リピドミクス

A Direct-Infusion MS/MSALL Approach for High-Throughput Untargeted Metabolomics

A Direct-Infusion MS/MSALL Approach for High-Throughput Untargeted Metabolomics


A Wellness Study Using Microflow Targeted Metabolomics to Investigate the Effects of Diet and Exercise on the Metabolome

A Wellness Study Using Microflow Targeted Metabolomics to Investigate the Effects of Diet and Exercise on the Metabolome


CESI-MS - A Sensitive and Versatile Approach for Metabolomics & Polar Molecules

CESI-MS - A Sensitive and Versatile Approach for Metabolomics & Polar Molecules


Mapping Desaturase Enzyme Activity in Complex Lipids by Ozone-Induced Dissociation

Mapping Desaturase Enzyme Activity in Complex Lipids by Ozone-Induced Dissociation


Simultaneous Quantitation/Profiling of Cell Culture Medium Components Using LC-MS/MS

Simultaneous Quantitation/Profiling of Cell Culture Medium Components Using LC-MS/MS

代謝物同定

Drug Metabolite Identification: Increasing the Separating Power of LC-MS with Differential Mobility Spectrometry and Chemical Modifiers

Drug Metabolite Identification: Increasing the Separating Power of LC-MS with Differential Mobility Spectrometry and Chemical Modifiers

食品

Metabolite Profiling in Fruit Juice Using X500B QTOF System for Determining its Antioxidant Activity

Metabolite Profiling in Fruit Juice Using X500B QTOF System for Determining its Antioxidant Activity

Screening and Quantitation in Food Matrices Using Combined SWATH® + IDA Acquisition

Screening and Quantitation in Food Matrices Using Combined SWATH® + IDA Acquisition

農薬

Quantitative Analysis of Dicamba and Related Acid Herbicides and Metabolites

Quantitative Analysis of Dicamba and Related Acid Herbicides and Metabolites

環境

Analysis of the Novel PFOA-Replacement Compound, GenX, by High Resolution and Triple Quadrupole Mass Spectrometry

Analysis of the Novel PFOA-Replacement Compound, GenX, by High Resolution and Triple Quadrupole Mass Spectrometry

Development of a Sensitive Quantitation Method for Analysis of Synthetic Azo Dyes in Textiles

Development of a Sensitive Quantitation Method for Analysis of Synthetic Azo Dyes in Textiles

Direct Evidence for the Origin of Bis-Gold Intermediates: Probing Gold Catalysis with Mass Spectrometry

Direct Evidence for the Origin of Bis-Gold Intermediates: Probing Gold Catalysis with Mass Spectrometry

Expanded Suspect Screening with SCIEX All-in-One MS/MS and NIST’17 MS/MS Libraries

This note describes the application of LC-MS/MS with Atmospheric Pressure Photo Ionization (APPI) for the determination of PBDE target congeners and HBCD stereoisomers in indoor dust samples and biological material.

新技術

A High-Throughput Mass Spectrometry Plate-Reader: Acoustic Droplet Ejection to an Open-Port Probe Sampling Interface

A High-Throughput Mass Spectrometry Plate-Reader: Acoustic Droplet Ejection to an Open-Port Probe Sampling Interface

Electromagnetic Mixer for Low-Response Paramagnetic Particles

Electromagnetic Mixer for Low-Response Paramagnetic Particles

Electron Capture Dissociation Device in a Branched RF Ion Trap on a QqToF Platform with Enhanced Duty Cycle

Electron Capture Dissociation Device in a Branched RF Ion Trap on a QqToF Platform with Enhanced Duty Cycle

Exploring the Figures of Merit of Differential Mobility Spectrometry (DMS) Cells of Varied Geometries

Exploring the Figures of Merit of Differential Mobility Spectrometry (DMS) Cells of Varied Geometries

Linear Dynamic Range Improvement in TOF-MS/MS Mode on X500 QTOF System

Linear Dynamic Range Improvement in TOF-MS/MS Mode on X500 QTOF System

Using Differential Mobility Spectrometry and Machine Learning-Based Modelling to Predict the Physicochemical Properties of Molecules

Using Differential Mobility Spectrometry and Machine Learning-Based Modelling to Predict the Physicochemical Properties of Molecules

Using Machine Learning to Maintain Instrument Reliability

Using Machine Learning to Maintain Instrument Reliability