For research use only. Not for use in diagnostic procedures.
The glycan notation used in BioPharmaView™ Software is the Oxford style, which is shown in column two of the table below.
The other nomenclature styles for glycans are also listed in the table, and each style is described and differentiated here:
Ludger Product Name (column 1): Most of these names use a nomenclature system that focuses on the number of sialic acid residues present. This nomenclature system is limited and is only able to describe a few simple glycans. For newer Ludger product names, the Oxford notation is preferred and is utilized instead.
Oxford Notation Name (column 2): This nomenclature system is based on building up the N-glycan structures, and has the capacity to name very complex glycans. Some of the nomenclature rules are listed here:
- All N-glycans have two core N-acetylglucosamine (GlcNAc) molecules.
- F at the start of the abbreviation indicates a core fucose.
- Mx is the number (x) of mannose molecules on the core GlcNAcs.
- Ax is the number of antenna molecules (GlcNAc) on a trimannosyl core.
- A2 indicates a biantennary compound, where both GlcNAcs are alpha1-2 linked.
- Gx is the number (x) of linked galactose on the antenna.
- G1 indicates that the galactose is on the antenna of the alpha1-3 or alpha1-6 mannose.
- Sx is the number (x) of sialic acids linked to galactose.
The Oxford notation can be used for bisecting GlcNAc molecules into tri- and tetra-antennary glycans and for denoting further substitutions such as fucose, sulphation, and phosophorylation. Numbers are also used to indicate linkages where known (e.g., F(6)A2G(4)2S(6)2 is a biantennary glycan with a core fucose in an alpha 6 linkage; the two galactoses are beta 1-4 linked; and the sialic acids are alpha 2-6 linked).
Short Name Used with IgG Glycans (column 3):This naming system, typically associated with IgG glycans, is primarily for indicating the presence of core fucose and the number of galactoses that are present on biantennary glycans. Only a limited number of structures can be described by this system, and the naming complexity increases when the structure is no longer a biantennary glycan (i.e., has only one GlcNAc antenna (-GN)).
Select a this link to download a pdf of the table above: Gycan Nomenclature - Ludger